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Webinar series 2022

 

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Past webinars

FEB
2 5:00 PM 7:00 PM CET
Eva Hoffmann
Head of Department of Cellular and Molecular Medicine, University of Copenhagen
Female meiosis - a molecular clock hypothesis

How do chromosome errors influence pregnancy loss, fertility, and congenital disorders in humans? The talk will cover the sex-specific aspect... see more

How do chromosome errors influence pregnancy loss, fertility, and congenital disorders in humans? The talk will cover the sex-specific aspects of meiosis in human females and the origins of aneuploidies. Chromosome errors in human eggs follow a U shape with age and we will discuss how this emerges and how it influences pregnancy loss.

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FEB
3 4:00 PM 7:00 PM CET
Sandra Moreno and Francesca Gioia Klinger
Associate Prof. in Developmental Biology and Associate Prof. in Histology and Embryology.
Stem cells: an overview and their role in reproduction

Stem cell research and regenerative medicine in male and female reproduction are growing enormously and many studies are aimed at their use i... see more

Stem cell research and regenerative medicine in male and female reproduction are growing enormously and many studies are aimed at their use in the clinic. During the webinar, a review of the most advanced results in the field will be provided.

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FEB
14 5:00 PM 7:00 PM CET
Marie-Madeleine Dolmans
Head of the Gynecology Research Unit at the Université Catholique de Louvain
Human ovarian tissue cryopreservation

During this open lecture guided by the gynaecologist and Head of the Gynecology Research Unit of Louvain University Marie-Madeleine Dolmans, ... see more

During this open lecture guided by the gynaecologist and Head of the Gynecology Research Unit of Louvain University Marie-Madeleine Dolmans, attendees will hear the latest results of ovarian tissue transplantation in humans, in terms of techniques, endocrine and fertility outcomes, graft lifespan and risks, and much more.

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FEB
17 5:00 PM 7:00 PM CET
Daniela Nogueira
IVF Director in Toulouse and nominated Scientific Director of the group Inovie Fertility
Human oocytes in vitro
maturation

This lecture includes the basic understanding of the in vitro oocyte maturation in humans, its applications, the clinical and laborator... see more

This lecture includes the basic understanding of the in vitro oocyte maturation in humans, its applications, the clinical and laboratory protocols used throughout the years of utilization of this technology. The influence of this strategy on rates of oocyte maturation and pre and post-implantation development will be thoroughly discussed.

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FEB
23 9:00 AM 11:00 AM CET
David K. Gardner
Scientific Director of Melbourne IVF, Professor in the School of BioSciences, University of Melbourne
In vitro embryo culture

Through the analysis of embryo nutrition and metabolism, combined with the analysis of oviduct and uterine fluids, the media used becam... see more

Through the analysis of embryo nutrition and metabolism, combined with the analysis of oviduct and uterine fluids, the media used became more physiological, and with the advent of sequential media blastocyst culture became a reality.

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MAR
1 5:00 PM 7:00 PM CET
Marcos Meseguer
Scientific Supervisor and Senior Embriologist, IVI-RMA Valencia, Spain
Time-Lapse microscopyin IVF

In this case, AI is employed in an indirect way to optimize the daily workflow based on existing traditional parameters. Finally, the most in... see more

In this case, AI is employed in an indirect way to optimize the daily workflow based on existing traditional parameters. Finally, the most innovative approach is the use of AI to directly predict pregnancy, implantation or even live birth by using only time-lapse images.

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MAR
3 5:00 PM 7:00 PM CET
Carlos Simón
Professor of Obstetrics & Gynecology, University of Valencia, Spain
The endometrial factor in periconceptional care

In this webinar, the contribution of the endometrial factor to the reproductive process will be discussed. The personalized molecular d... see more

In this webinar, the contribution of the endometrial factor to the reproductive process will be discussed. The personalized molecular diagnosis of the endometrial window of implantation, the understanding of the endometrial microbiome, the embryo-endometrial dialogue. Finally, evidence will be provided of a decidualization defect in the endometrium of women with severe preeclampsia affecting pregnancy.

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MAR
9 5:00 PM 7:00 PM CET
Giovanni Coticchio
Scientific Director of 9.baby, GeneraLife IVF, Bologna, Italy
Embryo plasticy: variations on development themes

With progressively novel information derived from Time Lapse technology, clinical embryology is called to re-define and re-interpret th... see more

With progressively novel information derived from Time Lapse technology, clinical embryology is called to re-define and re-interpret the diverse patterns of embryo development, dissect out possible mechanisms of self-correction from the background noise of abnormal morphokinetic manifestations, and reach an updated and more precise consensus on embryo viability. This presentation aims at illustrating this current endeavour, reporting atypical patterns of preimplantation development and discussing their relevance to human embryo viability.

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MAY
18 5:00 PM 7:00 PM CET
Alan Handyside
School of Biosciences, University of Kent, Canterbury, UK
The History of Preimplantation Genetic Testing

July 2020 marked the 30th anniversary of the first pregnancies and live births following IVF, embryo biopsy and single cell genetic ana... see more

July 2020 marked the 30th anniversary of the first pregnancies and live births following IVF, embryo biopsy and single cell genetic analysis in couples at risk of X-linked diseases. Since then, preimplantation genetic diagnosis (PGD), or preimplantation genetic testing for monogenic disease (PGT-M), as it has recently been renamed, has become well established as a valuable alternative to prenatal diagnosis for a wide range of inherited conditions and extended to chromosome abnormalities including aneuploidy and structural rearrangements. Today, there have been major advances in all aspects of preimplantation genetics that have revolutionised our ability to interrogate the genetics of human gametes and embryos.

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MAY
31 5:00 PM 7:00 PM CET
Nathan Treff
Chief Scientific Officer at Genomic Prediction, New York
Polygenic risk score as future perspective of IVF

Polygenic risk scoring in IVF embryo selection is a new approach which demonstrates significant relative risk reduction of several comm... see more

Polygenic risk scoring in IVF embryo selection is a new approach which demonstrates significant relative risk reduction of several common diseases including diabetes, cancer, and heart disease.  A review of existing literature, molecular genetic methodologies, common misconceptions, and ethical considerations will be presented.

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JUN
1 3:00 PM 4:00 PM CET
Luigi Naldini
Director of the Istituto San Raffaele Telethon per la Terapia Genica
Gene therapy

The main topic of this webinar is "Gene Therapy" and Luigi Naldini, Director of the Istituto San Raffaele Telethon per la Terapia Genic... see more

The main topic of this webinar is "Gene Therapy" and Luigi Naldini, Director of the Istituto San Raffaele Telethon per la Terapia Genica will guide us through it

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JUN
1 5:00 PM 7:00 PM CET
Carmen Rubio
Head of Research for embryonic chromosomal abnormalities at Igenomix, Valencia
Non-invasive Preimplantation Genetic Testing

Non-invasive PGT-A (niPGTA) is a new technique that allows the study of the chromosomal make up of an embryo. The informativity and the concordance rates for fresh embryos hav... see more

Non-invasive PGT-A (niPGTA) is a new technique that allows the study of the chromosomal make up of an embryo. The informativity and the concordance rates for fresh embryos have been related with the time in culture and the day of media collection (Rubio, 2020). This non-invasive approach could be applied for prioritization of embryo transfer after proper validation of specific algortithms.

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JUN
1 5:00 PM 7:00 PM CET
Carmen Rubio
Head of Research for embryonic chromosomal abnormalities at Igenomix, Valencia
Non-invasive Preimplantation Genetic Testing

Non-invasive PGT-A (niPGTA) is a new technique that allows the study of the chromosomal make up of an embryo. The informativity and the concordance rates for fresh embryos have been relat... see more

Non-invasive PGT-A (niPGTA) is a new technique that allows the study of the chromosomal make up of an embryo. The informativity and the concordance rates for fresh embryos have been related with the time in culture and the day of media collection (Rubio, 2020). This non-invasive approach could be applied for prioritization of embryo transfer after proper validation of specific algortithms

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JUN
15 5:00 PM 7:00 PM CET
Maurizio Poli and Alessandro Ori
Postdoctoral fellow at the European Molecular Biology Laboratory | Reproductive scientist and senior clinical embryologist
Non-invasive proteomics analysis

Proteins drive almost any biological function in living organisms, tightly orchestrated through complex molecular networks and post-translational modifications. Modern mass spectrom... see more

Proteins drive almost any biological function in living organisms, tightly orchestrated through complex molecular networks and post-translational modifications. Modern mass spectrometry-based proteomics provides an unbiased approach to study thousands of proteins in biological samples simultaneously and quantitatively. The lecture will include an introduction to principles of modern high-resolution mass spectrometry for proteomics, and computational strategies for identification and quantification of proteins and peptides. A specific focus will be on the measurement of global protein expression levels in different types of biological and clinical samples, as well as principles of biomarker discovery and validation.

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JUN
16 5:00 PM 7:00 PM CET
Antonio Capalbo
Genomic Research Director at Igenomix
Chromosomal mosaicism

Aneuploidy is extremely common in human embryos and is one of the main causes of unsuccessful IVF cycles. Aneuploidy in embryos mostly originates fro... see more

Aneuploidy is extremely common in human embryos and is one of the main causes of unsuccessful IVF cycles. Aneuploidy in embryos mostly originates from oocyte meiotic segregation errors, although post-zygotic errors, causative of chromosomal mosaicism in human blastocysts, may also occur. NGS has been suggested as an improved technology to report chromosomal mosaicism in trophectoderm biopsies. However, the use of subjective thresholds for mosaicism diagnosis has generated inconsistency across laboratories, with mosaicism prevalence estimates ranging from 2 to 40%.  As a matter of fact, to date, reporting mosaicism in PGT-A involved undeniable issues for the clinical management of PGT-A cycles and no clinical utility.

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JUN
17 2:00 PM 5:00 PM CET
Silvia Scaglione, Virginia Pensabene & Denny Sakkas
Silvia Scaglione, Founder and Chief Scientist of React4life; Virginia Pensabene, Associate Professor of Biomedical Electronics at Leeds University; Denny Sakkas, Chief Scientific Officer at Boston IVF
Basics of microfluidics and its application in reproduction & The IVF Lab on a chip: dream or reality?
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This webinar will gather three different lectures.

In the "Basics of microfluidics" lesson the students will obtain a  basic understanding of microfluidic devices and organ on chip, how they  are developed and how they work, which are their uses in the medical field thanks to Silvia Scaglione.

We will take a deep look to the application of microfluidics in reproduction with Virginia Pensabene, who will present a microfluidic approach for culturing embryos in vitro. The technological challenges to introduce the microfluidic method in clinics and the potential techniques to optimize the control of the microenvironment will be discussed. 

Last but not the least, Dr. Denny Sakkas will cover how automation is entering into the IVF lab, focusing on both Artificial Intelligence and Microfluidics. Novel new technologies will also be addressed including microscopy, robotics and the lab in a box. The final part of the talk will focus on how an embryologist will work in the lab of the future.

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